Where should sublingual medication be administered?

Sublingual medication is specifically designed to be administered under the tongue. This route allows the medication to dissolve quickly and be absorbed directly into the bloodstream through the mucous membranes in that area. The sublingual method bypasses the digestive system and first-pass metabolism in the liver, leading to faster onset of action and enhanced bioavailability of the drug.

The other options suggest methods that do not align with how sublingual medications are intended to be used. For instance, placing medication between the cheek and gums pertains to buccal administration, while applying it on the skin refers to topical medications. Administering medication with food is more relevant to oral medications which may require food to improve absorption, but it does not apply to sublingual medications that are meant to act independently of the gastrointestinal system.